Antibiotics application in biomaterials for soft and hard tissue implants

Abstract

One of the great challenges of modern medicine, pharmacy and chemistry as well is the treatment and replacement of damaged and injured soft and hard tissues, as well as bones and joints. Thus far variety of materials have been investigated and used in treating soft and hard tissues. On the other hand, application of soft or hard tissue implants brings high risk of infection by various microorganisms. Therefore, this paper presents the different possibilities of using soft and hard tissues implants particularly antibiotics-loaded implants with gradually releasing, with the aim to prevent bacterial infection, i.e. treat an infection that appeared as a result of the present microorganisms. The application of different antibiotics, gentamicin, ciprofloxacin, clindamycin, ampicillin, tetracycline, vancomycin for soft tissue implants as well as gentamicin and vancomycin as suitable antibiotics for hard tissue implants are reported.