Antibiotics application in biomaterials for soft and hard tissue implants
DOI:
https://doi.org/10.18485/uunt_gsc230101023oKeywords:
soft tissue implants, hard tissue implants, antibioticsAbstract
One of the great challenges of modern medicine, pharmacy and chemistry as well is the treatment and replacement of damaged and injured soft and hard tissues, as well as bones and joints. Thus far variety of materials have been investigated and used in treating soft and hard tissues. On the other hand, application of soft or hard tissue implants brings high risk of infection by various microorganisms. Therefore, this paper presents the different possibilities of using soft and hard tissues implants particularly antibiotics-loaded implants with gradually releasing, with the aim to prevent bacterial infection, i.e. treat an infection that appeared as a result of the present microorganisms. The application of different antibiotics, gentamicin, ciprofloxacin, clindamycin, ampicillin, tetracycline, vancomycin for soft tissue implants as well as gentamicin and vancomycin as suitable antibiotics for hard tissue implants are reported.
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Alavarse, A. C., de Oliveira Silva, F. W., Colque, J. T., da Silva, V. M., Prieto, T., Venancio, E. C., & Bonvent, J.-J. (2017). Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing. Materials Science & Engineering. C, Materials for Biological Applications, 77, 271–281. https://doi.org/10.1016/j.msec.2017.03.199
Cabrejos-Azama, J., Alkhraisat, M. H., Rueda, C., Torres, J., Pintado, C., Blanco, L., & López-Cabarcos, E. (2016). Magnesium substitution in brushite cements: Efficacy of a new biomaterial loaded with vancomycin for the treatment of Staphylococcus aureus infections. Materials Science and Engineering: C, 61, 72–78. https://doi.org/https://doi.org/10.1016/j.msec.2015.10.092
Charnley, J. (1960). Anchorage of the femoral head prosthesis to the shaft of the femur. The Journal of Bone and Joint Surgery. British Volume, 42-B, 28–30. https://doi.org/10.1302/0301-620X.42B1.28
Cohen, P. R., & Kurzrock, R. (2004). Community-acquired methicillin-resistant staphylococcus aureus skin infection: an emerging clinical problem. Journal of the American Academy of Dermatology, 50(2), 277–280. https://doi.org/https://doi.org/10.1016/j.jaad.2003.06.005
Coimbra, P., Freitas, J. P., Gonçalves, T., Gil, M. H., & Figueiredo, M. (2019). Preparation of gentamicin sulfate eluting fiber mats by emulsion and by suspension electrospinning. Materials Science and Engineering: C, 94, 86–93. https://doi.org/https://doi.org/10.1016/j.msec.2018.09.019
Eron, L. J., Lipsky, B. A., Low, D. E., Nathwani, D., Tice, A. D., & Volturo, G. A. (2003). Managing skin and soft tissue infections: Expert panel recommendations on key decision points. Journal of Antimicrobial Chemotherapy, 52(SUPPL. 1). https://doi.org/10.1093/jac/dkg466
Ghalme, S., Mankar, A., & Bhalerao, Y. (2016). Biomaterials in Hip Joint Replacement. International Journal of Materials Science and Engineering, 4, 113–125. https://doi.org/10.17706/ijmse.2016.4.2.113-125
Gluck, T. (2011). The Classic: Report on the Positive Results Obtained by the Modern Surgical Experiment Regarding the Suture and Replacement of Defects of Superior Tissue, as well as the Utilization of Re-absorbable and Living Tamponade in Surgery. Clinical Orthopaedics and Related Research®, 469(6), 1528–1535. https://doi.org/10.1007/s11999-011-1837-7
Guthrie, J., & Fitzpatrick, N. (2019). Single-Stage Revision of an Infected Total Hip Replacement Using Antibiotic-Impregnated Bioabsorbable Beads in a Canine Patient. VCOT Open, 02(01), e5–e12. https://doi.org/10.1055/s-0038-1677523
Hwang, M.-R., Kim, J. O., Lee, J. H., Kim, Y. il, Kim, J. H., Chang, S. W., Jin, S. G., Kim, J. A., Lyoo, W. S., Han, S. S., Ku, S. K., Yong, C. S., & Choi, H.-G. (2010). Gentamicin-loaded wound dressing with polyvinyl alcohol/dextran hydrogel: gel characterization and in vivo healing evaluation. AAPS PharmSciTech, 11(3), 1092–1103. https://doi.org/10.1208/s12249-010-9474-0
Ki, V., & Rotstein, C. (2008). Bacterial skin and soft tissue infections in adults: A review of their epidemiology, pathogenesis, diagnosis, treatment and site of care. Canadian Journal of Infectious Diseases and Medical Microbiology, 19(2), 173–184. https://doi.org/10.1155/2008/846453
Kim, J. O., Choi, J. Y., Park, J. K., Kim, J. H., Jin, S. G., Chang, S. W., Li, D. X., Hwang, M.-R., Woo, J. S., Kim, J.-A., Lyoo, W. S., Yong, C. S., & Choi, H.-G. (2008). Development of clindamycin-loaded wound dressing with polyvinyl alcohol and sodium alginate. Biological & Pharmaceutical Bulletin, 31(12), 2277–2282. https://doi.org/10.1248/bpb.31.2277
Kurczewska, J., Sawicka, P., Ratajczak, M., Gajęcka, M., & Schroeder, G. (2015). Will the use of double barrier result in sustained release of vancomycin? Optimization of parameters for preparation of a new antibacterial alginate-based modern dressing. International Journal of Pharmaceutics, 496(2), 526–533. https://doi.org/10.1016/j.ijpharm.2015.10.075
Lukáč, P., Hartinger, J. M., Mlček, M., Popková, M., Suchý, T., Šupová, M., Závora, J., Adámková, V., Benáková, H., Slanař, O., Bartoš, M., Chlup, H., Lambert, L., & Grus, T. (2019). A novel gentamicin-releasing wound dressing prepared from freshwater fish Cyprinus carpio collagen cross-linked with carbodiimide. Journal of Bioactive and Compatible Polymers, 34(3), 246–262. https://doi.org/10.1177/0883911519835143
Metsemakers, W. J., Kuehl, R., Moriarty, T. F., Richards, R. G., Verhofstad, M. H. J., Borens, O., Kates, S., & Morgenstern, M. (2018). Infection after fracture fixation: Current surgical and microbiological concepts. Injury, 49(3), 511–522. https://doi.org/10.1016/j.injury.2016.09.019
Monteiro, N., Martins, M., Martins, A., Fonseca, N. A., Moreira, J. N., Reis, R. L., & Neves, N. M. (2015). Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin. Acta Biomaterialia, 18, 196–205. https://doi.org/10.1016/j.actbio.2015.02.018
Navarro, M., Michiardi, A., Castaño, O., & Planell, J. A. (2008). Biomaterials in orthopaedics. Journal of The Royal Society Interface, 5(27), 1137–1158. https://doi.org/10.1098/rsif.2008.0151
Nnamani, O. (2013). Characterization and controlled release of gentamicin from novel hydrogels based on Poloxamer 407 and polyacrylic acids. African Journal of Pharmacy and Pharmacology, 7, 2540–2552. https://doi.org/10.5897/AJPP2013.3803
Păunică-Panea, G., Ghica, M. V., Marin, Ş., Ene, A. M., Marin, M. M., Dănilă, E., Niţipir, C., Albu, M. G., & Cristescu, I. (2015). Collagen-albumin-gentamicin hydrogels usable for infected wound healing. Leather and Footwear Journal, 15(4), 249–256. https://doi.org/10.24264/lfj.15.4.4
Pishbin, F., Mouriño, V., Flor, S., Kreppel, S., Salih, V., Ryan, M. P., & Boccaccini, A. R. (2014). Electrophoretic Deposition of Gentamicin-Loaded Bioactive Glass/Chitosan Composite Coatings for Orthopaedic Implants. ACS Applied Materials & Interfaces, 6(11), 8796–8806. https://doi.org/10.1021/am5014166
Puoci, F., Piangiolino, C., Givigliano, F., Parisi, O. I., Cassano, R., Trombino, S., Curcio, M., Iemma, F., Cirillo, G., Spizzirri, U. G., Restuccia, D., Muzzalupo, R., & Picci, N. (2012). Ciprofloxacin-collagen conjugate in the wound healing treatment. Journal of Functional Biomaterials, 3(2), 361–371. https://doi.org/10.3390/jfb3020361
Rajan, S. (2012). Skin and soft-tissue infections: classifying and treating a spectrum. Cleveland Clinic Journal of Medicine, 79(1), 57–66. https://doi.org/10.3949/ccjm.79a.11044
Roy, D. C., Tomblyn, S., Burmeister, D. M., Wrice, N. L., Becerra, S. C., Burnett, L. R., Saul, J. M., & Christy, R. J. (2015). Ciprofloxacin-Loaded Keratin Hydrogels Prevent Pseudomonas aeruginosa Infection and Support Healing in a Porcine Full-Thickness Excisional Wound. Advances in Wound Care, 4(8), 457–468. https://doi.org/10.1089/wound.2014.0576
Sabitha, M., & Rajiv, S. (2015). Preparation and characterization of ampicillin-incorporated electrospun polyurethane scaffolds for wound healing and infection control. Polymer Engineering & Science, 55(3), 541–548. https://doi.org/https://doi.org/10.1002/pen.23917
Sangnim, T., Limmatvapirat, S., Nunthanid, J., Sriamornsak, P., Sittikijyothin, W., Wannachaiyasit, S., & Huanbutta, K. (2018). Design and characterization of clindamycin-loaded nanofiber patches composed of polyvinyl alcohol and tamarind seed gum and fabricated by electrohydrodynamic atomization. Asian Journal of Pharmaceutical Sciences, 13(5), 450–458. https://doi.org/https://doi.org/10.1016/j.ajps.2018.01.002
Sripriya, R., Kumar, M. S., Ahmed, M. R., & Sehgal, P. K. (2007). Collagen bilayer dressing with ciprofloxacin, an effective system for infected wound healing. Journal of Biomaterials Science, Polymer Edition, 18(3), 335–351. https://doi.org/10.1163/156856207779996913
Stevanović, M., Đošić, M., Janković, A., Kojić, V., Vukašinović-Sekulić, M., Stojanović, J., Odović, J., Crevar Sakač, M., Rhee, K. Y., & Mišković-Stanković, V. (2018). Gentamicin-Loaded Bioactive Hydroxyapatite/Chitosan Composite Coating Electrodeposited on Titanium. ACS Biomaterials Science & Engineering, 4(12), 3994–4007. https://doi.org/10.1021/acsbiomaterials.8b00859
Stravinskas, M., Nilsson, M., Horstmann, P., Petersen, M. M., Tarasevicius, S., & Lidgren, L. (2018). Antibiotic Containing Bone Substitute in Major Hip Surgery: A Long Term Gentamicin Elution Study. Journal of Bone and Joint Infection, 3(2), 68–72. https://doi.org/10.7150/jbji.23901
van Vugt, T. A. G., Arts, J. J., & Geurts, J. A. P. (2019). Antibiotic-Loaded Polymethylmethacrylate Beads and Spacers in Treatment of Orthopedic Infections and the Role of Biofilm Formation. Frontiers in Microbiology, 10, 1626. https://doi.org/10.3389/fmicb.2019.01626
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